About 30 results found for searched term "ALK inhibitor 1" (0.099 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14877 | ALK inhibitor 1 | ALK |
| ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). | ||
| M28499 | ALK kinase inhibitor-1 | ALK |
| ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor. | ||
| M1743 | X-376 | ALK |
| X-376 is a potent and highly specific ALK small molecule tyrosine kinase inhibitor with IC50 of 0.61 nM. | ||
| M1942 | CH5424802 | ALK |
| Alectinib; AF802 | ||
| CH5424802 is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM. | ||
| M2075 | LDK378 | ALK |
| Ceritinib | ||
| LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM. | ||
| M2108 | SB-525334 | TGF-β Receptor |
| SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM. | ||
| M2199 | Camptothecin | Topoisomerase |
| Camptothecine; (S)-(+)-Camptothecin; CPT | ||
| Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. | ||
| M3781 | NVP-TAE684 | ALK |
| NVP-TAE684 is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM. | ||
| M3889 | LDN-214117 | ALK |
| LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM and >100 fold selectivity for ALK5. | ||
| M3975 | Lorlatinib (PF-06463922) | ALK |
| PF-06463922 | ||
| Lorlatinib (PF-06463922) is an oral active, selective, brain osmotic and ATP-competitive ROS1/ALK inhibitor. The Ki of Lorlatinib for ROS1, wild-type ALK and ALK(L1196M) were <0.025 nM, <0.07 nM and 0.7 nM, respectively. Lorlatinib has anticancer activity. | ||
| M4520 | (+)-Corydaline | AChR/AChE |
| (+)-Corydaline; Corydalin | ||
| Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. | ||
| M4811 | CH5424802 HCl | ALK |
| AF802 HCl; Alectinib Hydrochloride | ||
| CH5424802 HCl is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. | ||
| M4984 | CEP-37440 | ALK |
| CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). | ||
| M5038 | SD-208 | TGF-β Receptor |
| SD208 | ||
| SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. | ||
| M5161 | Sodium orthovanadate | ATPase |
| Sodium vanadate | ||
| Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. | ||
| M5220 | Piperlongumine | Others |
| PPLGM, Piplartine | ||
| Piperlongumine, a natural alkaloid from Piper longum L., is also a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1. | ||
| M5246 | EW-7197 | TGF-β Receptor |
| Vactosertib; TEW-7197 | ||
| EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. | ||
| M5613 | Entrectinib (RXDX-101) | ALK |
| NMS-E628; RXDX-101 | ||
| Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. | ||
| M6186 | Repotrectinib (TPX-0005) | ALK |
| TPX-0005; Repotrectinib | ||
| Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively. | ||
| M7177 | Quinine hydrochloride | Potassium Channel |
| Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M9246 | HUHS015 | Others |
| HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells. | ||
| M11530 | Guvacine | GABA Receptor |
| Guvacine, an alkaloid found in areca nut, is an effective inhibitor of GABA uptake. Guvacine inhibited rat GAT-1 with IC50 values of 39 μM, 58 μM and 378 μM, respectively. | ||
| M14147 | TPX-0131 | ALK |
| The CNS-penetrant ALK kinase inhibitor TPX-0131 was more potent in vitro against WT-ALK and many ALK resistance mutations than all five approved ALK inhibitors. | ||
| M14547 | Epiberberine chloride | AChR/AChE |
| Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. | ||
| M14944 | Vactosertib Hydrochloride | TGF-β Receptor |
| EW-7197 Hydrochloride; TEW-7197 Hydrochloride | ||
| Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. | ||
| M19236 | Arecaidine | GABA Receptor |
| Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. | ||
| M20633 | TP0427736 HCl | Src-bcr-Abl |
| TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. | ||
| M22527 | Cinchonidine | Alkaloids |
| α-Quinidine | ||
| Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Cinchonidine (α-Quinidine) is a weak inhibitor of serotonin transporter (SERT) with Ki values of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. | ||
| M24570 | Dalantercept | TGF-beta/Smad |
| ACE-041 | ||
| Dalantercept (ACE-041) is an activin receptor like kinase 1 (ALK1) inhibitor, a ligand trap for bone morphogenetic proteins (BMP) 9 and BMP 10. Dalantercept reduces tumor angiogenesis and delays tumor growth by binding to BMP 9 and BMP 10. As an anti angiogenic agent, Dalantercept has potential applications in persistent or recurrent ovarian cancer, renal cell carcinoma (RCC), and related malignant tumors. | ||
| M28756 | JH-VIII-157-02 | ALK |
| JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. | ||
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